Aspartate Aminotransferase (AST)

Why is AST important for your Healthspan?

‍Elevated AST levels can indicate damage to important organs like the liver and heart, which is important for long-term Healthspan. Monitoring AST helps identify potential organ distress or chronic conditions that, if left unaddressed, could impact health and longevity. Addressing the root cause of elevated AST protects organ function, reduces the risk of health events, and supports a longer, healthier life.

‍What is AST?

AST, or Aspartate Aminotransferase, is an enzyme involved in the metabolism of amino acids, particularly in the process of converting aspartate into other compounds for energy production. While AST is widely distributed throughout the body, it is found in higher concentrations in the heart muscle, skeletal muscles, kidneys, brain, and red blood cells, in addition to the liver. When cells in these organs are injured, inflamed, or diseased, AST can leak from within the cells into the bloodstream, leading to elevated levels detectable in a blood test. Although often measured alongside ALT (Alanine Aminotransferase), which is more specific to liver damage, an elevated AST that is higher than ALT can sometimes suggest damage originating from tissues other than the liver, such as the heart or muscles, or could indicate certain types of liver damage, like that caused by alcohol.

‍How do we take action?

If AST levels are found to be elevated, one should work with a healthcare provider to identify and address the underlying cause. This may involve further diagnostic tests to pinpoint the affected organ or condition. Lifestyle modifications such as adopting a balanced diet, limiting alcohol intake, and engaging in regular exercise can support organ health. It is also important to review all medications and supplements, as some can impact enzyme levels. Consistent monitoring of AST allows for tracking progress and ensuring organ function remains optimal, contributing to overall health and well-being.

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‍Additional resources

Giannini, E. G., Testa, R., & Savarino, V. (2005). Liver enzyme alteration: a guide for clinicians. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 172(3), 367–379. https://doi.org/10.1503/cmaj.1040752

Gowda, S., Desai, P. B., Hull, V. V., Math, A. A., Vernekar, S. N., & Kulkarni, S. S. (2009). A review on laboratory liver function tests. The Pan African medical journal, 3, 17.

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