Estrogen / Estradiol

Why is Estrogen important for your Healthspan?

‍Estrogen levels, maintained within an appropriate range for one's age and sex, are important for numerous physiological functions critical for Healthspan. In women, balanced estrogen supports bone density and cardiovascular health, which are key to maintaining mobility and reducing heart disease risk as they age. In both men and women, estrogen plays a role in cognitive function and skin health. Imbalances, whether too high or too low, can contribute to issues like bone loss, cardiovascular concerns, or mood disturbances that can impact long-term vitality and quality of life.

‍What is Estrogen?

Estrogen refers to a group of steroid hormones, primarily including Estradiol (E2), Estrone (E1), and Estriol (E3), with Estradiol being the most biologically active form. While often associated with female physiology, estrogen is produced in both women and men. In women, the ovaries are the main source, but it's also produced in smaller amounts by the adrenal glands and fat tissue. In men, the testes and adrenal glands produce estrogen, often through the conversion of testosterone. Estrogen plays a central role in the development and regulation of the female reproductive system and secondary sexual characteristics. Beyond reproduction, it influences bone density by regulating bone turnover, impacts cardiovascular health by affecting blood vessel elasticity and lipid profiles, contributes to brain function, and helps maintain skin integrity and hydration.

‍How do we take action?

If estrogen levels are outside the typical range, one should consult with a healthcare provider to understand the potential underlying causes and implications. For women, imbalances might relate to menstrual cycle irregularities, perimenopause, or menopause. In men, imbalances could be associated with symptoms like low libido or fatigue. Strategies often involve lifestyle modifications such as maintaining a healthy weight, engaging in regular physical activity, and consuming a balanced diet. Depending on the cause and symptoms, a healthcare provider might discuss specific medical interventions, including hormone therapy, to help restore balance and support overall Healthspan.

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‍Additional Sources

1. Wise, P. M., Suzuki, S., & Brown, C. M. (2009). Estradiol: a hormone with diverse and contradictory neuroprotective actions. Dialogues in clinical neuroscience, 11(3), 297–303. https://doi.org/10.31887/DCNS.2009.11.3/pmwise

2. Simpson E. R. (2003). Sources of estrogen and their importance. The Journal of steroid biochemistry and molecular biology, 86(3-5), 225–230. https://doi.org/10.1016/s0960-0760(03)00360-1

3. Tulchinsky, D., Hobel, C. J., Yeager, E., & Marshall, J. R. (1972). Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. American journal of obstetrics and gynecology, 112(8), 1095–1100. https://doi.org/10.1016/0002-9378(72)90185-8

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