Neutrophil-to-Lymphocyte Ratio

Why is the Neutrophil/Lymphocyte Ratio (NLR) important for your Healthspan?

‍The Neutrophil to Lymphocyte Ratio is a well-researched marker of inflammation, which is a key factor in the development of many age-related conditions. A high NLR can signal a state of chronic low-grade inflammation, suggesting an imbalance in the immune system's response to stress or other underlying health issues. If left unaddressed, this state can impact long-term health and increase the risk of chronic diseases. Monitoring this ratio can help guide strategies to reduce inflammation and support long-term vitality.

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‍What is the NLR?

The Neutrophil to Lymphocyte Ratio (NLR) is a calculated value derived by dividing the absolute neutrophil count by the absolute lymphocyte count from a complete blood count (CBC) with differential. Neutrophils are the most abundant type of white blood cell and serve as the immune system's first responders to acute infections and inflammation. Lymphocytes are a different type of white blood cell that are central to the body's long-term immune memory and response. An elevated NLR suggests a shift in the immune system, with a relative increase in neutrophils and a decrease in lymphocytes, which is a common pattern observed during periods of physiological stress, acute or chronic inflammation, or infection.

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How do we take action?

If the Neutrophil to Lymphocyte Ratio is elevated, one should consult with a healthcare provider to investigate the potential sources of systemic inflammation. Strategies often involve adopting an anti-inflammatory lifestyle through a balanced diet, regular physical activity, and effective stress management. Addressing any underlying infections, autoimmune conditions, or other chronic diseases is also important. Regular monitoring of the NLR can help track the effectiveness of interventions aimed at reducing the inflammatory burden and supporting overall Healthspan."

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