Heart health

Atherogenic index of plasma (AIP)

AIP

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A research index built from triglycerides and HDL.

The atherogenic index of plasma (AIP) is calculated from your triglyceride and HDL cholesterol results. Researchers use it to summarize the balance between these two blood fats, and studies link higher values with heart disease.

It's the TG/HDL ratio on a different scale.

AIP is the logarithm of your triglycerides divided by your HDL cholesterol, both in mmol/L. It carries the same information as your TG/HDL ratio, so the two always rise and fall together.

In research, a higher AIP is linked with smaller, denser LDL particles and with coronary artery disease. Studies use different cut-offs, and Canadian guidelines don't set one, so it's best read as supporting context.

A higher AIP means more triglycerides relative to HDL cholesterol.

Questions

What does a higher AIP mean?

It means your triglycerides are high relative to your HDL cholesterol. In studies, this pattern is associated with insulin resistance and higher heart disease risk. Your clinician reads it with your LDL cholesterol, ApoB, HbA1c, and blood pressure.

Can AIP be a negative number?

Yes. When your triglycerides are lower than your HDL cholesterol, the logarithm gives a value below zero. A negative result is expected in that case, and it reflects relatively low triglycerides compared with HDL.

Why might my AIP change between tests?

Triglycerides shift with recent meals, alcohol, and activity, while HDL usually changes more slowly. A recent meal before your draw can push AIP up, so comparing results over time tells you more than one reading.

Sources and references