Metabolic health
Lignoceric acid (C24:0)
Tetracosanoic acid
Included in Complete.
Compare membershipsOne of the longest saturated fats in your profile.
Lignoceric acid is a saturated fat with a long chain of 24 carbons. It helps build sphingolipids, a family of fats in cell membranes, and peanuts are among the richest food sources of this type of fat.
Its links with health run opposite to palmitic acid's.
Saturated fats are often discussed as one group. In large prospective studies, though, higher blood levels of very long-chain saturated fats, including lignoceric acid, have been associated with lower risk of type 2 diabetes, heart failure, and atrial fibrillation.
These studies are observational, so they show links without proving cause. In one pooled analysis, the diabetes link disappeared once researchers accounted for triglycerides and palmitic acid.
Saturated fats come in different lengths, and they may not act alike.
Questions
Is a higher lignoceric acid level good news?
In research, higher levels have been associated with better cardiometabolic outcomes. A single result can't tell you your personal risk, so it's best read with your other fatty acids, triglycerides, and health history.
Can this result point to an inherited fatty acid disorder?
This profile isn't designed to check for them. Rare inherited conditions, such as X-linked adrenoleukodystrophy, cause very long-chain fats to build up. They're assessed with a separate, specialized very long-chain fatty acid test and genetic testing, which a clinician orders when symptoms or family history suggest it.
Sources and references
- Lemaitre and King, Very long-chain saturated fatty acids and diabetes and cardiovascular disease (Curr Opin Lipidol, 2022)
- Fretts et al., Circulating very-long-chain saturated fatty acids and incident type 2 diabetes, pooled analysis of prospective cohorts (Am J Clin Nutr, 2019)
- MedlinePlus Genetics, X-linked adrenoleukodystrophy
- GeneReviews (NCBI Bookshelf), X-linked adrenoleukodystrophy
