Heart and cholesterol
Apolipoprotein B (ApoB)
Included in every MyHealthspan membership: Focus, Baseline, and Complete.
Compare membershipsA clearer picture of your heart health.
ApoB helps estimate the number of cholesterol-carrying particles in your blood that can contribute to plaque buildup in your arteries. Alongside your cholesterol results, it adds useful information about your cardiovascular risk.
Your usual cholesterol panel may not include ApoB.
A routine cholesterol panel typically measures total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. For many MyHealthspan members, this is the first time they've had their ApoB tested.
LDL cholesterol tells you how much cholesterol is carried inside LDL particles. ApoB helps estimate how many potentially plaque-forming particles are circulating, including LDL and other types. Two people can have similar LDL cholesterol levels but different numbers of these particles, so an LDL result within the lab's reference range may not tell the whole story.
LDL cholesterol measures the cargo. ApoB helps count the carriers.
Questions
What does a higher ApoB result mean?
A higher ApoB level generally indicates more potentially plaque-forming particles circulating in your blood. Your result should be read alongside your other blood markers, blood pressure, health history, and other cardiovascular risk factors.
Does ApoB show whether I already have plaque?
No. ApoB helps assess risk, but it doesn't show whether plaque is already present or diagnose heart disease on its own.
Can ApoB change over time?
Yes. ApoB can change with eating habits, metabolic health, and cholesterol-lowering treatment. A clinician can help you set a personal target and decide whether repeat testing would be useful.
Sources and references
- Canadian Cardiovascular Society, 2021 dyslipidemia guidelines (Pearson et al., Can J Cardiol)
- Sniderman et al., Apolipoprotein B particles and cardiovascular disease: a narrative review (JAMA Cardiol, 2019)
- Glavinovic et al., Physiological bases for the superiority of ApoB over LDL-C and non-HDL-C (J Am Heart Assoc, 2022)
